Warning: NAs introduced by coercion
Warning: NAs introduced by coercionExecutive Summary
Background
Previously, the client implemented a Kaplan-Meier survival curve to model the survival predictions across different types of dementia.
Client’s Aims
The client has two aims for this project. The first is to produce an interactive graph that provides a comprehensive exploration of the time from formal diagnosis to death based on four key covariates: age at diagnosis, sex, disease duration at diagnosis, and overall cognitive performance measured by the ACE-III test. These covariates were selected by the client based on their expertise and the availability of data. The second aim is to explore additional variables, including those from the Cambridge Behavioural Inventory-Revised carer questionnaire, family history of dementia as defined by a Goldman Score, and cognitive abilities. The client suspects these variables may influence survival rates and wants more clarity on the extent of the impact each factor has on survival.
Model
To meet the client’s objective of understanding how various covariates affect different dementia patient groups, we implemented a Cox Proportional Hazards regression model for each type of dementia, serving as the foundation of the interactive survival graph. This approach was informed by previous client analyses that highlighted statistically significant survival differences across dementia diagnoses. Each model accounted for age at diagnosis, sex, disease duration at diagnosis, and overall cognitive performance as assessed by the ACE-III test. While the Cox regression model does not assume any underlying data distribution, it does require other assumptions to be satisfied (details in the appendix).
Interactive Survival Graph
The interactive survival graph is designed to facilitate the analysis of different patient groups by inputting their specific data. This feature allows users to observe and compare how various factors impact survival rates across different groups. As shown in the graph, users can select patient attributes such as age at diagnosis, disease duration, ACE-III total scores, and gender, along with specific dementia diagnoses. By adjusting these parameters, the graph dynamically illustrates the survival probabilities over time, enabling a detailed comparison between two distinct patient groups.
Patient Group 1
Patient Group 2
Significance of variables
Overall significance for all dementia diagnosis
Since there is no censored data, we applied the survreg function with a “lognormal” distribution to fit a parametric survival regression model.
The dataset exhibits multicollinearity, which means some variables are highly correlated. For example, “ACE-III Total” is the total score on the Addenbrooke’s Cognitive Examination-III test (the sum of all other ACE-III columns). Multicollinearity is likely to result in unreliable coefficient estimation and difficult interpretation. Thus, we applied the Variance Inflation Factor (VIF) to detect multicollinearity. VIF values show the strength of the correlation between the independent variables. To avoid problems caused by multicollinearity, we only considered variables with lower VIF values. The variables with lower VIF values can display characteristics of omitted variables, so we did not lose information from the dataset.
We scaled the data to ensure data in the same scale, so the variables with a high magnitude of coefficient have a more significant influence on our dependent variable “Diagnosis till death”. For the full model considering all variables, we presented a bar plot to visualise the top 4 significant variables:
- Disease duration at diagnosis: the number of years the person has been experiencing symptoms before coming into the clinic.
- ACEIII::SubtotalFluency: An examination of the integrity of verbal fluency by a cognitive screening tool.
- ACEIII::SubtotalVisuospatial: An examination of the integrity of visuospatial by a cognitive screening tool.
- CBI::PercentSelfCareFCorrected: The percentages of the maximum achievable score in self-care examines by The Cambridge Behavioural Inventory-Revised (CBI-R). Higher scores denote better performance in self care.
The variables shown in orange play a positive impact on the model, and the variables shown in blue play a negative impact on the model.
More details for the full model are listed in the Appendix.
Significance of variabes by dementia group
AD bvFTD CBS
49 61 25
FTD-MND lvPPA nfvPPA
35 27 29
nfvPPA + Parkinson’s plus PSP svPPA
13 21 21 
These are nine different dementia groups. We counted the number of observations for each group. Since there are no sufficient observations in the “nfvPPA + Parkinson’s plus” group, “PSP” group, and “svPPA” group, there is an overfitting. The insufficient data probably leads to a model that is overly tailored to samples by capturing noise rather than the underlying pattern.
Besides, from previous analysis, we found “Diagnosis_number” plays an important role, so we constructed models for dementia groups with enough data. From above plots, we visualised significant variables for each dementia group.
- AD: “ACEIII::SubtotalVisuospatial” has a positive impact, and “EducationYearsTotal” and “Age at diagnosis” have a negative impact on “Diagnosis till death”.
- bvFTD: “CBI::PercentMemory”, “ACEIII::SubtotalVisuospatial”, and “ACEIII::SubtotalFluency” have a positive impact, and “CBI::PercentSelfCare” has a negative impact on “Diagnosis till death”.
- CBS: There are many variables having impact on “Diagnosis till death”. “ACEIII::SubtotalAttention” has a positive impact, and “CBI::PercentEating” and “CBI::PercentAbnormal” have a negative impact.
- FTD-MND: There are many variables having impact on “Diagnosis till death”. “Sex (Male 1, Female 2)” and “Disease duration at diagnosis” have a positive impact, and “CBI::PercentAbnormal” has a negative impact.
- lvPPA: There are many variables having impact on “Diagnosis till death”. “CBI::PercentSelfCare” and “ACEIII::SubtotalLanguage” have a positive impact, and “CBI::PercentAbnormal” has a negative impact.
- nfvPPA: “Sex (Male 1, Female 2)”, “CBI::PercentEating”, “ACEIII::SubtotalFluency” have a postive impact, and “ACEIII::SubtotalAttention” has a negative impact on “Diagnosis till death”.
It is same as the previous bar plot. The variables shown in orange and blue play a positive and negative impact on the model respectively. We can conclude “ACEIII::SubtotalVisuospatial”, “ACEIII::SubtotalFluency”, “CBI::PercentSelfCare”, “ACEIII::SubtotalAttention”, “CBI::PercentEating”, “CBI::PercentAbnormal” are significant for most dementia groups.
More details for the each dementia group model are listed in the Appendix.
Appendix
Testing Proportional Harzard
| Covariate | Chisq | Degrees of Freedom | p-value |
|---|---|---|---|
| Age at diagnosis | 1.24 | 1 | 0.266 |
| Sex | 1.35 | 1 | 0.246 |
| Disease duration at diagnosis | 0.17 | 1 | 0.682 |
| ACE-III Total | 1.09 | 1 | 0.297 |
| GLOBAL | 3.25 | 4 | 0.517 |
| Covariate | Chisq | Degrees of Freedom | p-value |
|---|---|---|---|
| Age at diagnosis | 0.42 | 1 | 0.517 |
| Sex | 6.61 | 1 | 0.010 |
| Disease duration at diagnosis | 0.41 | 1 | 0.523 |
| ACE-III Total | 1.02 | 1 | 0.312 |
| GLOBAL | 9.12 | 4 | 0.058 |
| Covariate | Chisq | Degrees of Freedom | p-value |
|---|---|---|---|
| Age at diagnosis | 0.05 | 1 | 0.826 |
| Sex | 1.88 | 1 | 0.170 |
| Disease duration at diagnosis | 0.01 | 1 | 0.933 |
| ACE-III Total | 1.64 | 1 | 0.200 |
| GLOBAL | 3.87 | 4 | 0.424 |
| Covariate | Chisq | Degrees of Freedom | p-value |
|---|---|---|---|
| Age at diagnosis | 0.36 | 1 | 0.548 |
| Sex | 0.05 | 1 | 0.824 |
| Disease duration at diagnosis | 0.84 | 1 | 0.358 |
| ACE-III Total | 4.50 | 1 | 0.034 |
| GLOBAL | 6.95 | 4 | 0.139 |
| Covariate | Chisq | Degrees of Freedom | p-value |
|---|---|---|---|
| Age at diagnosis | 0.00 | 1 | 0.992 |
| Sex | 0.12 | 1 | 0.731 |
| Disease duration at diagnosis | 2.92 | 1 | 0.088 |
| ACE-III Total | 0.01 | 1 | 0.905 |
| GLOBAL | 3.86 | 4 | 0.425 |
| Covariate | Chisq | Degrees of Freedom | p-value |
|---|---|---|---|
| Age at diagnosis | 0.08 | 1 | 0.782 |
| Sex | 1.50 | 1 | 0.220 |
| Disease duration at diagnosis | 4.85 | 1 | 0.028 |
| ACE-III Total | 1.57 | 1 | 0.211 |
| GLOBAL | 10.68 | 4 | 0.030 |
| Covariate | Chisq | Degrees of Freedom | p-value |
|---|---|---|---|
| Age at diagnosis | 0.12 | 1 | 0.734 |
| Sex | 0.05 | 1 | 0.832 |
| Disease duration at diagnosis | 1.25 | 1 | 0.263 |
| ACE-III Total | 0.78 | 1 | 0.377 |
| GLOBAL | 2.34 | 4 | 0.674 |
| Covariate | Chisq | Degrees of Freedom | p-value |
|---|---|---|---|
| Age at diagnosis | 0.15 | 1 | 0.702 |
| Sex | 0.07 | 1 | 0.796 |
| Disease duration at diagnosis | 0.14 | 1 | 0.705 |
| ACE-III Total | 2.46 | 1 | 0.117 |
| GLOBAL | 2.87 | 4 | 0.579 |
| Covariate | Chisq | Degrees of Freedom | p-value |
|---|---|---|---|
| Age at diagnosis | 0.12 | 1 | 0.734 |
| Sex | 0.00 | 1 | 0.972 |
| Disease duration at diagnosis | 0.39 | 1 | 0.530 |
| ACE-III Total | 0.76 | 1 | 0.384 |
| GLOBAL | 3.47 | 4 | 0.483 |
Results from all dementia diagnosis
| Coefficient | Std. Error | z value | p value | |
|---|---|---|---|---|
| (Intercept) | 1.6287042 | 0.0991719 | 16.4230431 | 0.0000000 |
| Diagnosis_nameFTD-MND | -1.3149343 | 0.1465575 | -8.9721390 | 0.0000000 |
| Log(scale) | -0.6053870 | 0.0421825 | -14.3516303 | 0.0000000 |
| Diagnosis_namenfvPPA + Parkinson’s plus | -0.2807378 | 0.1883152 | -1.4907868 | 0.1360175 |
| Diagnosis_namelvPPA | -0.2083461 | 0.1400319 | -1.4878470 | 0.1367912 |
| Diagnosis_namenfvPPA | -0.1942113 | 0.1576234 | -1.2321225 | 0.2179033 |
| ACEIII::SubtotalFluency | 0.1758444 | 0.0477791 | 3.6803610 | 0.0002329 |
| ACEIII::SubtotalVisuospatial | 0.1300042 | 0.0559673 | 2.3228600 | 0.0201867 |
| CBI::PercentSelfCareFCorrected | -0.1291601 | 0.0496838 | -2.5996408 | 0.0093321 |
| Sex (Male 1, Female 2) 2 | 0.1117217 | 0.0726728 | 1.5373244 | 0.1242139 |
| CBI::PercentMemoryFCorrected | 0.1082240 | 0.0557348 | 1.9417675 | 0.0521652 |
| ACEIII::SubtotalMemory | -0.0980801 | 0.0644657 | -1.5214318 | 0.1281515 |
| Diagnosis_namebvFTD | -0.0789263 | 0.1392427 | -0.5668258 | 0.5708326 |
| Disease duration at diagnosis | 0.0776235 | 0.0361458 | 2.1475100 | 0.0317527 |
| CBI::PercentMotivationFCorrected | -0.0761239 | 0.0533105 | -1.4279338 | 0.1533109 |
| Age at diagnosis | -0.0621485 | 0.0376262 | -1.6517348 | 0.0985886 |
| CBI::PercentAbnormalFCorrected | -0.0554625 | 0.0575207 | -0.9642179 | 0.3349367 |
| Diagnosis_namesvPPA | 0.0506025 | 0.1866061 | 0.2711727 | 0.7862582 |
| Diagnosis_namePSP | -0.0503900 | 0.1746879 | -0.2884574 | 0.7729967 |
| ACEIII::SubtotalAttention | 0.0499284 | 0.0620538 | 0.8045995 | 0.4210508 |
| ClinicalAssessment::GoldmanScore | 0.0471112 | 0.0355100 | 1.3267019 | 0.1846073 |
| CBI::PercentSleepFCorrected | -0.0468760 | 0.0396049 | -1.1835893 | 0.2365757 |
| Diagnosis_nameCBS | -0.0467270 | 0.1698713 | -0.2750732 | 0.7832600 |
| CBI::PercentEverydayFCorrected | -0.0387882 | 0.0580971 | -0.6676443 | 0.5043607 |
| CBI::PercentMoodFCorrected | 0.0335674 | 0.0504296 | 0.6656296 | 0.5056479 |
| CBI::PercentBeliefsFCorrected | 0.0168583 | 0.0374950 | 0.4496140 | 0.6529888 |
| EducationYearsTotal | 0.0100432 | 0.0371356 | 0.2704470 | 0.7868164 |
| CBI::PercentStereotypicalFCorrected | 0.0074927 | 0.0546087 | 0.1372075 | 0.8908668 |
| ACEIII::SubtotalLanguage | -0.0072250 | 0.0622213 | -0.1161174 | 0.9075595 |
| CBI::PercentEatingFCorrected | -0.0030126 | 0.0564909 | -0.0533295 | 0.9574693 |
Results from each dementia diagnosis
| Coefficient | Std. Error | z value | p value | |
|---|---|---|---|---|
| (Intercept) | 1.9750823 | 0.1304882 | 15.1361021 | 0.0000000 |
| Log(scale) | -1.0695636 | 0.1010153 | -10.5881398 | 0.0000000 |
| ACEIII::SubtotalVisuospatial | 0.3234895 | 0.0731973 | 4.4194162 | 0.0000099 |
| CBI::PercentEating | 0.2350261 | 0.1710496 | 1.3740229 | 0.1694346 |
| Age at diagnosis | -0.2089849 | 0.0555404 | -3.7627564 | 0.0001681 |
| CBI::PercentSelfCare | -0.1704212 | 0.1295625 | -1.3153584 | 0.1883895 |
| EducationYearsTotal | -0.1431628 | 0.0674650 | -2.1220319 | 0.0338351 |
| Sex (Male 1, Female 2) 2 | 0.1286976 | 0.1178721 | 1.0918412 | 0.2749029 |
| ACEIII::SubtotalLanguage | -0.1268934 | 0.1546210 | -0.8206738 | 0.4118321 |
| Disease duration at diagnosis | -0.1220367 | 0.0729627 | -1.6725902 | 0.0944080 |
| ACEIII::SubtotalAttention | 0.1068610 | 0.1215558 | 0.8791107 | 0.3793413 |
| CBI::PercentAbnormal | -0.0803797 | 0.1685262 | -0.4769568 | 0.6333929 |
| ACEIII::SubtotalFluency | -0.0736457 | 0.0967825 | -0.7609406 | 0.4466925 |
| GoldmanScore | 0.0730915 | 0.1044951 | 0.6994732 | 0.4842564 |
| CBI::PercentMotivation | -0.0712989 | 0.1096646 | -0.6501540 | 0.5155927 |
| CBI::PercentSleep | -0.0653759 | 0.0751421 | -0.8700306 | 0.3842837 |
| CBI::PercentStereotypical | -0.0629505 | 0.1336806 | -0.4709021 | 0.6377107 |
| ACEIII::SubtotalMemory | 0.0517398 | 0.1237023 | 0.4182605 | 0.6757567 |
| CBI::PercentMemory | -0.0411183 | 0.1035539 | -0.3970718 | 0.6913145 |
| CBI::PercentMood | 0.0392490 | 0.0953593 | 0.4115904 | 0.6806397 |
| CBI::PercentBeliefs | -0.0282680 | 0.0972206 | -0.2907617 | 0.7712336 |
| CBI::PercentEveryday | 0.0050338 | 0.1057047 | 0.0476213 | 0.9620180 |
| Coefficient | Std. Error | z value | p value | |
|---|---|---|---|---|
| (Intercept) | 1.5303344 | 0.1170029 | 13.0794614 | 0.0000000 |
| Log(scale) | -0.8642163 | 0.0905357 | -9.5455812 | 0.0000000 |
| ACEIII::SubtotalVisuospatial | 0.3778851 | 0.1298433 | 2.9103170 | 0.0036106 |
| Sex (Male 1, Female 2) 2 | 0.2886560 | 0.1653018 | 1.7462366 | 0.0807698 |
| ACEIII::SubtotalFluency | 0.2565609 | 0.0770503 | 3.3297847 | 0.0008691 |
| CBI::PercentMemory | 0.2381783 | 0.0976174 | 2.4399175 | 0.0146906 |
| CBI::PercentMotivation | -0.1902755 | 0.1033317 | -1.8414041 | 0.0655624 |
| CBI::PercentSelfCare | -0.1681407 | 0.0732513 | -2.2953961 | 0.0217104 |
| CBI::PercentEveryday | 0.1342125 | 0.1096458 | 1.2240559 | 0.2209312 |
| CBI::PercentMood | 0.1280998 | 0.0833549 | 1.5367993 | 0.1243425 |
| CBI::PercentAbnormal | -0.1038375 | 0.0903971 | -1.1486811 | 0.2506875 |
| Age at diagnosis | -0.0719060 | 0.0708841 | -1.0144167 | 0.3103840 |
| Disease duration at diagnosis | 0.0638477 | 0.0551819 | 1.1570405 | 0.2472558 |
| ACEIII::SubtotalMemory | 0.0593544 | 0.1088862 | 0.5451044 | 0.5856817 |
| ACEIII::SubtotalLanguage | -0.0566174 | 0.1236980 | -0.4577070 | 0.6471629 |
| CBI::PercentStereotypical | -0.0359267 | 0.0909457 | -0.3950342 | 0.6928176 |
| CBI::PercentBeliefs | -0.0344206 | 0.0472027 | -0.7292072 | 0.4658749 |
| EducationYearsTotal | -0.0305323 | 0.0749984 | -0.4071060 | 0.6839301 |
| GoldmanScore | 0.0272971 | 0.0433647 | 0.6294791 | 0.5290355 |
| CBI::PercentSleep | -0.0235812 | 0.0687799 | -0.3428496 | 0.7317116 |
| ACEIII::SubtotalAttention | -0.0116516 | 0.1224109 | -0.0951844 | 0.9241683 |
| CBI::PercentEating | -0.0043376 | 0.0854637 | -0.0507537 | 0.9595217 |
| Coefficient | Std. Error | z value | p value | |
|---|---|---|---|---|
| Log(scale) | -2.5074648 | 0.1414214 | -17.7304536 | 0.0000000 |
| (Intercept) | 1.2601504 | 0.0813703 | 15.4866045 | 0.0000000 |
| ACEIII::SubtotalAttention | 0.6429914 | 0.0924133 | 6.9577794 | 0.0000000 |
| CBI::PercentAbnormal | -0.6081172 | 0.1485806 | -4.0928443 | 0.0000426 |
| CBI::PercentEating | -0.5693867 | 0.2192432 | -2.5970548 | 0.0094027 |
| Age at diagnosis | -0.3749717 | 0.0397285 | -9.4383467 | 0.0000000 |
| ACEIII::SubtotalFluency | -0.3596098 | 0.0783762 | -4.5882543 | 0.0000045 |
| ACEIII::SubtotalLanguage | 0.2561218 | 0.0901964 | 2.8396030 | 0.0045170 |
| Disease duration at diagnosis | 0.2549515 | 0.0475947 | 5.3567202 | 0.0000001 |
| ACEIII::SubtotalMemory | -0.2291749 | 0.1057606 | -2.1669206 | 0.0302409 |
| ACEIII::SubtotalVisuospatial | -0.1924689 | 0.0468063 | -4.1120264 | 0.0000392 |
| CBI::PercentMotivation | 0.1909696 | 0.0645523 | 2.9583709 | 0.0030927 |
| CBI::PercentMemory | 0.1740816 | 0.0795944 | 2.1871083 | 0.0287346 |
| CBI::PercentStereotypical | 0.1740530 | 0.1266023 | 1.3748014 | 0.1691930 |
| CBI::PercentBeliefs | 0.1633968 | 0.0623610 | 2.6201742 | 0.0087885 |
| CBI::PercentSleep | 0.1619915 | 0.0562377 | 2.8804782 | 0.0039707 |
| GoldmanScore | 0.1399078 | 0.0498079 | 2.8089447 | 0.0049704 |
| CBI::PercentEveryday | -0.1254057 | 0.0928637 | -1.3504274 | 0.1768789 |
| Sex (Male 1, Female 2) 2 | -0.0498895 | 0.0914201 | -0.5457171 | 0.5852604 |
| CBI::PercentSelfCare | 0.0191061 | 0.0787067 | 0.2427508 | 0.8081984 |
| EducationYearsTotal | 0.0189151 | 0.0368374 | 0.5134742 | 0.6076196 |
| CBI::PercentMood | 0.0076438 | 0.0579347 | 0.1319384 | 0.8950330 |
| Coefficient | Std. Error | z value | p value | |
|---|---|---|---|---|
| Disease duration at diagnosis | 1.2358327 | 0.1325214 | 9.3255344 | 0.0000000 |
| Log(scale) | -1.1623290 | 0.1195229 | -9.7247417 | 0.0000000 |
| Sex (Male 1, Female 2) 2 | 0.9278389 | 0.2189638 | 4.2374072 | 0.0000226 |
| CBI::PercentAbnormal | -0.7573791 | 0.1153260 | -6.5672913 | 0.0000000 |
| (Intercept) | 0.7440880 | 0.1048109 | 7.0993354 | 0.0000000 |
| ACEIII::SubtotalFluency | 0.5266696 | 0.0878011 | 5.9984373 | 0.0000000 |
| CBI::PercentSelfCare | -0.4768137 | 0.1604920 | -2.9709504 | 0.0029688 |
| CBI::PercentEveryday | 0.4269279 | 0.1913710 | 2.2308912 | 0.0256883 |
| CBI::PercentSleep | 0.3911099 | 0.0964967 | 4.0530894 | 0.0000505 |
| CBI::PercentMotivation | 0.3800288 | 0.1054487 | 3.6039195 | 0.0003135 |
| CBI::PercentStereotypical | 0.3773127 | 0.1193792 | 3.1606229 | 0.0015743 |
| ACEIII::SubtotalVisuospatial | -0.3649682 | 0.1723536 | -2.1175557 | 0.0342127 |
| CBI::PercentEating | -0.2980087 | 0.1297252 | -2.2972311 | 0.0216056 |
| GoldmanScore | -0.2946542 | 0.0716841 | -4.1104531 | 0.0000395 |
| ACEIII::SubtotalLanguage | 0.2907866 | 0.1230162 | 2.3638076 | 0.0180882 |
| ACEIII::SubtotalMemory | 0.2434248 | 0.1375060 | 1.7702854 | 0.0766796 |
| Age at diagnosis | -0.2315923 | 0.1109884 | -2.0866352 | 0.0369211 |
| CBI::PercentMood | 0.2129421 | 0.1105221 | 1.9266921 | 0.0540180 |
| CBI::PercentBeliefs | -0.1845847 | 0.1034678 | -1.7839817 | 0.0744266 |
| EducationYearsTotal | 0.1306507 | 0.0952751 | 1.3712994 | 0.1702816 |
| CBI::PercentMemory | -0.0740127 | 0.1231594 | -0.6009502 | 0.5478731 |
| ACEIII::SubtotalAttention | -0.0224537 | 0.1301940 | -0.1724635 | 0.8630732 |
| Coefficient | Std. Error | z value | p value | |
|---|---|---|---|---|
| (Intercept) | 1.8026096 | 0.1209581 | 14.9027656 | 0.0000000 |
| Log(scale) | -1.6674571 | 0.1360828 | -12.2532574 | 0.0000000 |
| CBI::PercentSelfCare | 1.4020805 | 0.2238965 | 6.2621819 | 0.0000000 |
| CBI::PercentAbnormal | -0.6431153 | 0.1610063 | -3.9943497 | 0.0000649 |
| ACEIII::SubtotalLanguage | 0.6034872 | 0.0958470 | 6.2963588 | 0.0000000 |
| Age at diagnosis | -0.5169174 | 0.0752091 | -6.8730720 | 0.0000000 |
| ACEIII::SubtotalMemory | -0.3792927 | 0.1358856 | -2.7912649 | 0.0052502 |
| Sex (Male 1, Female 2) 2 | 0.3643523 | 0.1147199 | 3.1760158 | 0.0014931 |
| Disease duration at diagnosis | 0.3573427 | 0.1005937 | 3.5523380 | 0.0003818 |
| CBI::PercentStereotypical | 0.3484087 | 0.1180543 | 2.9512583 | 0.0031648 |
| CBI::PercentMood | -0.3461832 | 0.1049336 | -3.2990700 | 0.0009701 |
| CBI::PercentEveryday | -0.3000232 | 0.0746338 | -4.0199351 | 0.0000582 |
| ACEIII::SubtotalFluency | 0.2770906 | 0.0874911 | 3.1670741 | 0.0015398 |
| GoldmanScore | -0.2643619 | 0.0837359 | -3.1570927 | 0.0015935 |
| CBI::PercentMemory | -0.2117017 | 0.1189139 | -1.7802942 | 0.0750278 |
| CBI::PercentBeliefs | -0.1757078 | 0.1523796 | -1.1530929 | 0.2488722 |
| CBI::PercentSleep | -0.1253179 | 0.0928932 | -1.3490534 | 0.1773198 |
| ACEIII::SubtotalAttention | 0.0785194 | 0.1326390 | 0.5919781 | 0.5538653 |
| CBI::PercentMotivation | 0.0647494 | 0.1056918 | 0.6126246 | 0.5401246 |
| EducationYearsTotal | 0.0539759 | 0.0587912 | 0.9180949 | 0.3585692 |
| ACEIII::SubtotalVisuospatial | -0.0466682 | 0.1493251 | -0.3125279 | 0.7546394 |
| CBI::PercentEating | 0.0387899 | 0.1308310 | 0.2964889 | 0.7668568 |
| Coefficient | Std. Error | z value | p value | |
|---|---|---|---|---|
| (Intercept) | 1.3547831 | 0.3874500 | 3.4966660 | 0.0004711 |
| Log(scale) | -1.0773595 | 0.1313064 | -8.2049254 | 0.0000000 |
| CBI::PercentEating | 1.0274441 | 0.4081958 | 2.5170376 | 0.0118346 |
| ACEIII::SubtotalAttention | -0.7660366 | 0.3165456 | -2.4199878 | 0.0155210 |
| CBI::PercentSelfCare | -0.5565359 | 0.6558621 | -0.8485563 | 0.3961282 |
| ACEIII::SubtotalFluency | 0.5051080 | 0.1546901 | 3.2652894 | 0.0010935 |
| CBI::PercentAbnormal | -0.4995772 | 0.2653886 | -1.8824364 | 0.0597768 |
| Sex (Male 1, Female 2) 2 | 0.4792632 | 0.1926135 | 2.4882116 | 0.0128387 |
| Disease duration at diagnosis | -0.2879376 | 0.1480755 | -1.9445316 | 0.0518314 |
| ACEIII::SubtotalVisuospatial | 0.2876360 | 0.2855660 | 1.0072491 | 0.3138151 |
| CBI::PercentMood | 0.2815494 | 0.1576189 | 1.7862668 | 0.0740561 |
| CBI::PercentStereotypical | -0.2402609 | 0.2051067 | -1.1713945 | 0.2414402 |
| CBI::PercentMotivation | -0.2310093 | 0.1794759 | -1.2871324 | 0.1980481 |
| ACEIII::SubtotalMemory | 0.1961746 | 0.2373103 | 0.8266587 | 0.4084305 |
| CBI::PercentBeliefs | 0.1676204 | 0.9042686 | 0.1853658 | 0.8529421 |
| ACEIII::SubtotalLanguage | -0.1363656 | 0.2832484 | -0.4814346 | 0.6302077 |
| GoldmanScore | 0.1231585 | 0.2982228 | 0.4129749 | 0.6796250 |
| CBI::PercentSleep | 0.0974343 | 0.1751731 | 0.5562172 | 0.5780624 |
| Age at diagnosis | -0.0701088 | 0.1005063 | -0.6975563 | 0.4854547 |
| CBI::PercentMemory | 0.0644035 | 0.1824586 | 0.3529758 | 0.7241066 |
| EducationYearsTotal | -0.0228537 | 0.1797444 | -0.1271453 | 0.8988254 |
| CBI::PercentEveryday | -0.0154270 | 0.2513615 | -0.0613739 | 0.9510614 |
Contribution
Linh Trinh - Analysis and Report writing. Betty Zhao - Analysis and Report writing.